Cell Therapy

Our goal is to enable physicians to unlock their patient’s natural healing potential
using safe, effective, evidence-based cell therapy.

What are stem cells?

Stem cells serve as the starting material of the body and are the precursor to all other cell types. Stem cells are unspecialized cells capable of transforming into a range of other cell types but also able to replicate themselves to produce more stem cells. The body uses stem cells to heal and regenerate tissues by activating the stem cells to mature into the type of cell needed by the body.

Stem Cell Differentiation
Stem Cell
Mesenchymal Stem Cell graphic
cycle arrow graphic
Self renewal
Three arrow
Ectoderm
Ectoderm scientific graphic
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skin cell graphic
Skin Cell
nerve cell graphic
Nerve Cell
Mesoderm
graphic of a mesoderm
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bone cartilage graphic
Cartilage Cell
tendon in muscle graphic
Tendon Cell
Endoderm
Endoderm scientific graphic
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Hepatocyte beta cell graphic
Hepatocyte
pancreatic cell scientific graphic
Pancreatic Cell

What is Stem Cell Therapy?

Like the phrase “stem cell” itself, “stem cell therapy” is often used to describe a variety of different medical therapies that utilize stem cells in some form to treat a patient. Sometimes the term is used incorrectly to refer to platelet rich plasma (PRP) injections. The term is also used to refer to stem cell transplants, also known as bone marrow transplants.

Most commonly “stem cell therapy” is used to describe a procedure where the patient’s adult stem cells and other potentially regenerative cells are harvested from a tissue sample of either fat or bone marrow taken from the patient. These regenerative cells are then used to treat specific injuries typically by injecting them into the affected area. It should be said that this type of stem cell therapy is currently not FDA approved and clinics performing these therapies in the US are doing so without regulatory oversight.

At InGeneron we use the term “regenerative cell therapy” since there are many different cell types and regenerative properties collected and used by our therapy along with adult stem cells. Importantly we do not treat patients outside of our approved clinical trials and we are dedicated to developing ethical FDA approved therapies through rigorous clinical research.

Dr. Alt extracting stem cells from the processing unit

What Are ADRCs?

Regenerative cells are cell types that naturally promote tissue regeneration and homeostasis by facilitating the generation of new cells to replace old or injured cells in a particular tissue. Adipose-derived regenerative cells, also known as Stromal Vascular Fraction, are cells isolated from adipose (fat) tissue, where they are found in high concentrations.

Regenerative cells include stem cells, notably vaPS cells, and MSCs, which can mature into multiple cell types, progenitor cells, macrophages, and other cell types that promote tissue regeneration and healing.

These cells work together by responding to inputs from their surrounding through a complex system of signaling, resulting in synergistic healing effects that are greater than the effect that any one cell type can have on its own. Multiple studies show that ADRCs can be effective in treating a variety of soft tissue and bone conditions and have a high safety profile.

Adipose (fat) Tissue
Adipose-derived regenerative cells graphic Mesenchymal Stem Cell graphic Mesenchymal Stem Cells (MSC) M2 Macrophage cell graphic M2 Macrophages Endothelial Progenitor Cells graphic Endothelial Progenitor Cells Vascular-Associated Pluripotent Stem Cells (vaPS) graphic Vascular-Associated Pluripotent Stem Cells (vaPS)

What is the Transpose RT process?

A small sample of adipose tissue, containing regenerative cells, is taken from the patient using a mini-liposuction procedure. The sample is then transferred into a processing tube of the Transpose® RT kit, and the proprietary Matrase® enzymatic reagent is added to the sample before it is inserted into the Transpose® RT Processing Unit.

During the first run, efficient enzymatic extracellular degradation liberates the regenerative cells from their surrounding matrix. Subsequent washing and filtering steps prepare these cells for immediate therapeutic application. The entire procedure can be completed within a few hours in an outpatient facility.

Fat tissue mini-liposuction
Arrow 1 Physician harvests 100ml adipose tissue
Regenerative cells with adipose fat tissue
Arrow 2 Regenerative cells isolated using processing unit & enzyme
InGeneron’s Transpose® RT processing unit
Arrow
Regenerative cells ready for treatment. Mesenchymal Stem Cells (MSC). Vascular-associated Pluripotent Stem (vaPS) Cells. Endothelial Progenitor Cells. M2 Macrophages.
Arrow 3 Local injection into the affected tissue
Regenerative cell injection into rotator cuff tear