Cell Therapy

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How InGeneron’s Therapy Works

Simply put, we help doctors help patients heal themselves by harvesting adipose-derived regenerative cells (ADRCs) from the patient’s body fat; isolating these autologous cells from the fat tissue using an enzyme-based process; and then washing, filtering, and injecting them into the part of the patient’s body that needs repair.

Our therapy is designed to repair injured tissue, improve patients’ quality of life, and modify the progression of their disease.

Our current focus is on several specific medical conditions: partial rotator cuff tears, facet joint syndrome and wrist osteoarthritis.

ADRCs are initially removed from patients using liposuction in an outpatient, clinical setting with no need for expensive equipment or complicated processing. The time span from when patients arrive for the procedure to when they leave the clinic is approximately two hours.

Why use a patient’s adipose tissue?

Harvesting cells from adipose tissue is less invasive than other stem cell removal techniques such as bone marrow aspirations, and it yields significantly more adherent cells per unit volume than bone marrow. Treatment with these autologous cells

isolated from fat avoids common transplantation issues, such as the rejection of cells or the transmission of disease, and it does not require antirejection or immunosuppressant drugs, because the cells originate from the patient’s own body.

Advantages of InGeneron’s ADRC technology

    Adipose-derived regenerative cells have the potential to show a wide range of regenerative functions including but not limited to the following properties and mechanisms.
  • ADRCs are a heterogeneous population of cells that exhibit a wide range of cellular functions and promote healing.
  • ADRCs promote the repair and regeneration of damaged tissue by stimulating neighboring cells through direct contact and the release of factors.
  • Mesenchymal stem cells are a component of the ADRCs and can potentially help repair damaged tissue.
  • ADRCs have immune-modulating functions and can act as strong anti-inflammatory agents and promote healing.

How InGeneron Compares to Other Cell Therapy Techniques

InGeneron’s cell therapy platform utilizes a patient’s autologous regenerative cells. Autologous means the cells are taken from and reintroduced into the same patient. Alternatively other cell therapies utilize allogenic cells which typically come from a bank of donor cells cultured in a lab. Using autologous cells has been shown to be safer and more effective than allogenic cells. A comparison of two recent studies can be shown below

 
PERFORMANCE OF AUTOLOGOUS VS. ALLOGENIC CELLS

 

Basic Stem Cell Science

InGeneron aims to provide physicians and patients an overview of relevant publications in the field of regenerative medicine. Bellow, find a selection of basic literature as well as relevant publications in potential areas where InGeneron’s technology might be applied.

 

Shoulder biopsy publication X-Ray

First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature

Alt, E., Rothoerl, R., Hoppert, M., Frank, H. G., Wuerfel, T., Alt, C., & Schmitz, C.,
World J Stem Cells. 2021 Jul 26;13(7):944-970.

PubMed    |   PDF    |   DOI

Mouse articular injury publication

Aging alters tissue resident mesenchymal stem cell properties

Alt, E. U., Senst, C,. Murthy, S. N., Slakey, D. P., Dupin, C. L., Chaffin, A. E., Kadowitz, P. J., Izadpanah, R.,
Stem Cell Research. 2012 Mar;8(2):215-25.

PubMed    |   PDF    |   DOI

Fibroblast

InGeneron STEM Cells

Differentiation and Plasticity of Stem Cells for Tissue Engineering

Song, YH., Prantl, L., Alt, E. U.,
Tissue Engineering. 2011:113-30.

 PDF    |   DOI

Cardiovascular System

InGeneron has pioneered stem cell and cell therapy research for more than 15 years. View the latest Publications from InGeneron Below.

Publications